Preparation and characterization of sorafenib-loading microcapsules by complex coacervation of gum Arabic with chitosan or modified chitosan

Sorafenib is an oral multi-target kinase inhibitor that has been used to treat unresectable hepatocellular carcinoma and advanced renal cell carcinoma. The aim of the study was prepare gum Arabic-chitosan (GA-CS) Arabic-modified chitosan (GA-MCS) microcapsules containing sorafenib as core phase by complex coacervation. fluorescence microscopy, dynamic light scattering (DLS), drug loading, encapsulation efficiency were clarified. GA-MCS microcapsule successfully performed at approximate pH 4 with a 1% modified -to- 5% Arabic ratio 5:1 (v/v), while GA-CS prepared 3.5 volume 1:1 (v/v). encapsulated in shown through microscopy images. formation hydrodynamic sizes 6.31 μm 6.56 μm, respectively, achieved. loading greater than microcapsule. findings indicated could be appropriate load high yield.